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The University of California, Irvine Radiation Oncology Program is committed to creating an interdisciplinary, team-based culture of safety and to adhere to the highest standards of patient care, quality assurance, and quality improvement. Oncology treatment, and radiation therapy especially, is highly complex; it relies on numerous healthcare workers operating together cohesively at the highest level. In order to continuously offer the highest quality care, UCI prioritizes creating a safe environment, having a system to report and analyze near misses and errors, reducing waste, standardizing and automating workflows, performing peer review, and recalibrating clinical processes when needed. The Department of Radiation Oncology at UCI is firmly committed to quality and safety in everything we do and is taking the lead to develop new standards for practices across the country.