UCI study reveals critical role of new brain circuits in improving learning and memory for Alzheimer’s disease treatment

Irvine, Calif. – September 23, 2019 - A University of California, Irvine-led team of scientists has discovered how newly identified neural circuits in the brain’s hippocampal formation play a critical role in object-location learning and memory.

The study, published today in Nature Neuroscience, was led by Xiangmin Xu, PhD, an anatomy and neurobiology professor in the UCI School of Medicine, and conducted in collaboration with Douglas A. Nitz, PhD, professor and chair of the Department of Cognitive Science at the University of California, San Diego; Qing Nie, PhD, Chancellor's Professor of mathematics and developmental and cell biology at UCI; and, Todd C. Holmes, professor and vice chair of UCI’s Department of Physiology & Biophysics.  

Loss of object location memory is one of the key impairments in Alzheimer’s disease (AD), the most common form of dementia in the elderly.   These new findings in hippocampal circuit mechanisms provide an intriguing new target to counteract AD-related memory impairments. 

“Our study was made possible by new viral genetic based mapping approaches for examining connectivity between structures.  These new mapping tools enabled us to identify novel circuits within and between the hippocampus and cortex,” said Xu. 

Xu and his colleagues used monosynaptic rabies retrograde tracing and herpes (H129)-based anterograde tracing to establish new cortico-hippocampal circuitry associated with subiculum (SUB) projections to hippocampal CA1. Xu and an international team of investigators was recently awarded an NIH BRAIN Initiative grant to develop new H129 viral tracers as a brain mapping tool for use by the entire neuroscience community.

The team revealed the hippocampal sub-circuit mechanism highly relevant to learning and memory disorders including Alzheimer's disease.  These findings may be used to better treat Alzheimer’s disease and other neurological disorders, delay their onset, and possibly prevent them from developing in the first place.

This study was supported by the National Institutes of Health, including a BRAIN Initiative grant and other grants, the National Science Foundation, and the Simons Foundation.

About the UCI School of Medicine

Each year, the UCI School of Medicine educates more than 400 medical students and nearly 150 PhD and MS students. More than 700 residents and fellows are trained at the UCI Medical Center and affiliated institutions. Multiple MD, PhD and MS degrees are offered. Students are encouraged to pursue an expansive range of interests and options. For medical students, there are numerous concurrent dual degree programs, including an MD/MBA, MD/MPH, or an MD/MS degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Program in Medical Education for Leadership Education to Advance Diversity-African, Black and Caribbean (PRIME LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit medschool.uci.edu.