UC Irvine-led study links metabolism changes in certain brain cells to Huntington’s disease — Findings show high-dose thiamine and biotin treatments can restore normal processes Posted: 2022-12-21 Source: UC Irvine News News Type: Press Release share Findings from a study led by UCI’s Ryan Lim and Leslie Thompson validate that the mutation that causes HD leads to impairments in the cell maturation process of the myelin-producing cells that are critical for neuronal health and function, and help clarify how high doses of thiamine and biotin are an effective therapeutic approach. Ryan Lim/UCI and Steve Zylius/UCI Media Contacts Matt Miller Director mrmille2@uci.edu Michelle Heath Manager mstrombe@hs.uci.edu Shani Murray Senior Science Writer shanim@hs.uci.edu Communications & PR Office Related Faculty/Staff Leslie Thompson, PhD Professor, Psychiatry & Human Behavior Professor, Biological Chemistry