Nov 14, 2024 | UC Irvine News

UC Irvine-led study reveals new insights into how we navigate space and store memories

Researchers led by the University of California, Irvine are the first to reveal how two neural circuits located in the brain’s retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer’s disease and other cognitive disorders by allowing them to target pathway-specific neural circuits.

Oct 31, 2024 | UC Irvine School of Medicine

UC Irvine Researchers Develop Innovative CRISPR-Cas9 Method to Understand Antiviral Defense Response

A UC Irvine research team led by Rémi Buisson have developed a new, unbiased method utilizing CRISPR-Cas9 technology to identify novel regulators of the human antiviral defense response.

Oct 04, 2024 | UC Irvine News

UC Irvine researchers are first to reveal role of ophthalmic acid in motor function control

A research team from the University of California, Irvine is the first to reveal that a molecule in the brain — ophthalmic acid — unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson’s and other movement diseases.

Oct 03, 2024 | UC Irvine News

UC Irvine receives initial $33 million in federal support for vaccine research

Philip Felgner, PhD, professor in residence in the Department of Physiology & Biophysics, and director of UC Irvine’s Adeline Yen Mah Vaccine Center, will lead a multi-institutional pandemic planning effort with this $33 million grant from the National Institute of Allergy and Infectious Diseases.

Sep 27, 2024 | UC Irvine News

Circadian disruption, gut microbiome changes linked to colorectal cancer progression

Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function.

Sep 05, 2024 | UC Irvine News

UC Irvine, USC scientists begin research effort for damaged brain region treatments

With newly awarded funding from the National Science Foundation, researchers at UC Irvine and the Keck School of Medicine of USC will seek to revolutionize the treatment of neurological diseases through intelligent biocomputing.

Aug 21, 2024 | UC Irvine News

UC Irvine discovery of ‘item memory’ brain cells offers new Alzheimer’s treatment target

Researchers from the University of California, Irvine have discovered the neurons responsible for “item memory,” deepening our understanding of how the brain stores and retrieves the details of “what” happened and offering a new target for treating Alzheimer’s disease.

Aug 20, 2024 | UC Irvine News

UC Irvine-led team finds that compound in rosemary extract can reduce cocaine sensitivity

A team of researchers led by the University of California, Irvine has discovered that an antioxidant found in rosemary extract can reduce volitional intakes of cocaine by moderating the brain’s reward response, offering a new therapeutic target for treating addiction.

Aug 06, 2024 | UC Irvine News

UC Irvine-led team reveals how TREM2 genetic mutation affects late-onset Alzheimer’s

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer’s disease. Their first-of-their-kind insights into brain effects could yield new targets for early intervention.

Jul 31, 2024 | UC Irvine News

UC Irvine Institute for Clinical & Translational Science receives $28 million NIH grant

The Institute for Clinical & Translational Science at the University of California, Irvine has been awarded more than $28 million over seven years from the National Institutes of Health as part of its Clinical & Translational Science Awards Program.