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Jun 28, 2024 | UCI School of Medicine
UC Irvine researchers investigate muscle cell development in muscular dystrophy
Facioscapulohumeral muscular dystrophy (FHSD) is one of the most common muscular dystrophies, which results in progressive weakening of skeletal muscles. Now, a new study published in Genome Research by UCI School of Medicine researchers utilize cutting-edge single-cell spatial transcriptomics to analyze gene expression in individual nuclei and myocytes of disease and control samples to determine how the disease state develops during human skeletal myocyte differentiation.
Jun 10, 2024 | UCI News
‘Cutting the cable’ between CD8+ T and T regulatory cells enhances checkpoint immunotherapy
A UCI-led multidisciplinary research team has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor, a discovery that may offer a new strategy for improving melanoma treatment.
Jun 10, 2024 | UCI School of Medicine
UC Irvine researchers project cardiac benefits from weight-loss medication tirzepatide
New study finds that popular weight-loss medication may reduce the number of U.S. adults with obesity by 55 million and prevent up to 2 million heart attacks and strokes over a 10-year period.
May 28, 2024 | UCI News
UC Irvine study reveals circadian clock can be leveraged to enhance cancer immunotherapy
A multidisciplinary research team at UCI has revealed that the circadian clock can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy, offering new avenues for prevention and treatment.
May 14, 2024 | UCI News
UC Irvine-led study links sleep apnea severity during REM stage to verbal memory decline
A research team led by the University of California, Irvine, has revealed the link between the frequency of sleep apnea events during the rapid-eye-movement stage and the severity of verbal memory impairment in older adults at risk for Alzheimer’s disease.
Apr 26, 2024 | UCI School of Medicine
UC Irvine study resolves the function of a key vision-supporting protein in cellular-level detail
Researchers at the University of California, Irvine have discovered a pivotal role for cellular retinaldehyde protein (CRALBP) in the retinal pigmented epithelium (RPE) in supporting the physiology of the light-sensing cells in our eyes, known as photoreceptors.
Apr 25, 2024 | UCI School of Medicine
UCI researchers identified Alzheimer’s disease brain neural circuit alterations
A new study published in "The Journal of Neuroscience" by UCI School of Medicine researchers explores how Alzheimer's disease (AD) affects the brain's wiring, concentrating on a specific brain area called the subiculum, one of the first brain areas impacted by AD.
Apr 24, 2024 | UCI News
UC Irvine to lead study of how DNA genetic variations might influence nicotine addiction
A three-year, $1.19 million grant from the Tobacco-Related Disease Research Program will allow University of California, Irvine, researchers to explore how specific sections of DNA might influence nicotine addiction. Findings may improve prevention and treatment strategies for smoking and vaping habits.
Apr 15, 2024 | UCI School of Medicine
UC Irvine-led research team shows importance of under-recognized genetic factor lipoprotein(a) in predicting heart disease in a large multiethnic US population
In what is the largest, most ethnically diverse long-term study of a U.S. population, a UC Irvine research team found that an under-recognized genetic cholesterol-like particle called lipoprotein(a) can help predict future cardiovascular disease.
Apr 05, 2024 | UCI News
UC Irvine-led research team builds first tandem repeat expansions genetic reference maps
Tool gives potential to expand insight into diseases, neurological disorders and cancers.