New findings reveal why only some cancers respond to ATR inhibitor therapy

UC Irvine researchers gain a better understanding of which types of cancer cells are more sensitive to ATR inhibitor therapy and identify biomarkers that can predict patients’ responses to treatment.

New findings explore how cells fight viruses without harming themselves

A study by UC Irvine researchers examines how our bodies activate defense mechanisms only in the presence of a virus, ensuring that uninfected, healthy cells are not harmed.

UC Irvine School of Medicine Reaches Semifinals of STAT Madness

UC Irvine School of Medicine’s research team has made it through to the Semifinals of STAT Madness, an annual competition by STAT that brings together the best biomedical research from the past year. Research from institutions across the country face off against each other in a bracket-style matchup in which votes determine the winner.

UC Irvine researchers found links that may provide therapeutic targets for neurological diseases

Wei Li, PhD, UC Irvine School of Medicine

Nuclear speckles identified as key hubs for gene expression regulation

UCI researchers, including Yongsheng Shi, PhD, professor in the Department of Microbiology and Molecular Genetics, and first author Yoseop Yoon, PhD, uncover the critical role of nuclear speckles as the major site of pre-mRNA 3' end processing.

UC Irvine-led team discovers potential new therapeutic targets for Huntington’s disease

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington’s disease and link HD with other neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal lobar dementia and Alzheimer’s disease.

Career Pathways: Part 16

Cholsoon Jang, PhD, assistant professor in the Departments of Biological Chemistry and Medicine, shares how the COVID-19 pandemic impacted his journey to UC Irvine School of Medicine and how curiosity has driven his scientific journey from a very early age.

New mechanism discovered that triggers immune response in cells with damaged DNA

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This finding could lead to more effective cancer treatments.

The Mystery of What’s Causing Young People’s Cancer Leads to the Gut

Selma Masri, PhD, associate professor in the Department of Biological Chemistry, shares her research and understanding of the microbiome, contributing to our understanding of the cause of increasing cancer cases among young people.

UC Irvine Researchers Develop Innovative CRISPR-Cas9 Method to Understand Antiviral Defense Response

A UC Irvine research team led by Rémi Buisson have developed a new, unbiased method utilizing CRISPR-Cas9 technology to identify novel regulators of the human antiviral defense response.