Aug 10, 2017 | PubMed

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

Our findings indicate that the clock operates at the crossroad between protein acetylation, liver metabolism, and aging.

Aug 10, 2017 | UC Irvine News

Link between biological clock and aging revealed

In a study appearing today in the journal Cell, Paolo Sassone-Corsi, director of the Center for Epigenetics & Metabolism at the University of California, Irvine, and colleagues reveal how circadian rhythms – or the body’s biological clock – change as a result of physiological aging.

Jul 06, 2016 | Neuron

Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons

These studies illuminate the critical role of D2R-mediated signaling in regulating the activity of striatal cholinergic interneurons and the mechanisms of typical antipsychotic side effects.