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Graphic data that describes increased DNA damage in neurons from SCA7 patients

Nov 30, 2021 | UC Irvine School of Medicine

UCI-led study confirms linkage between altered DNA repair and DNA damage in neurodegenerative conditions causing debilitating movement disorders

New research suggests potential therapies to treat spinocerebellar ataxia and its resulting coordination impairments
Description of how two high-throughput screening (HTS) identify the next generation of medications

Nov 16, 2021 | UC Irvine School of Medicine

UCI-led team develops new screening process, could lead to next-generation therapeutics for a broad spectrum of diseases

High-throughput screening provides insight into functional role of key G protein-coupled receptor (GPCR) rhodopsin (Rh)
Picture of UCI's multidisciplinary team of researchers

Nov 15, 2021 | UC Irvine School of Medicine

Multidisciplinary team from UCI publishes new guidance for neuroscience statistical analysis; New guide will lead to more rigorous analysis, reproducibility and richer conclusions

New guide will lead to more rigorous analysis, reproducibility and richer conclusions
Picture of Californian Coast Redwood Forest land

Nov 15, 2021 | UC Irvine School of Medicine

UCI-led study finds single molecule within a specific plant used by Native Americans can treat both pain and diarrhea

UCI-led study finds single molecule within a specific plant used by Native Americans can treat both pain and diarrhea
Microscope image of PIEZO1

Nov 09, 2021 | UC Irvine School of Medicine

UCI researchers reveal critical role of mechanosensor in skin wound healing

PIEZO1, an ion channel mechanosensor found within cells, has been revealed to play a key role in regulating the speed of skin wound healing.
Xiangmin Xu, PhD, and his colleagues at the UCI Center for Neural Circuit Mapping

Nov 08, 2021 | UC Irvine School of Medicine

UCI Center for Neural Circuit Mapping Investigators receive funding from three federal awards for a total of more than $7M

The University of California, Irvine Center for Neural Circuit Mapping (CNCM) has been awarded three new grants.
Dr. Daniele Piomelli in office

Oct 22, 2021 | UC Irvine School of Medicine

UCI-led study first to reveal specific molecular mechanism that controls the transition from acute to chronic pain

A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.
computer renderings of classic and the hypervirulent C. difficile

Oct 22, 2021 | UC Irvine School of Medicine

UCI-led study suggests new molecular target for therapeutic interventions aimed at C. difficile infection

A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease.
Chairmen in Falling Leaves Foundations posing for the picture

Sep 20, 2021 | UC Irvine News

Falling Leaves Foundation $30 million lead gift to fund innovative UCI medical research building

Facility to be designed to advance cross-disciplinary teaching, translational research activities
Activation of the GRHL3/FSCN1/E-cadherin pathway in wounded skin cells

Sep 08, 2021 | UC Irvine School of Medicine

UCI-led research uncovers new mechanism that promotes wound healing in skin

A University of California, Irvine-led study identifies a new molecular pathway that promotes the healing of wounds in the skin. Titled, “GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization,” the study was published today in JCI Insight.