New prediction algorithm identifies previously undetected cancer driver genes

Leveraging public data reveals new information about genetic and epigenetic alterations and their roles in cancer.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies

A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

New UCI-led study reveals how skin cells prepare to heal wounds

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.

Skin and non-adhesive cells on the skin’s surface found to play pivotal role in the formation of fingers and toes

Human fingers are sculpted from a primitive pad-like structure during embryonic development. Sometimes, this process goes awry and babies are born with fused fingers or toes. A new study from the University of California, Irvine reveals new factors involved in the congenital malformation called syndactyly.

New discovery may drive the development of better, more effective immunotherapies for the treatment of breast cancer

New cancer immunotherapy approaches are revolutionizing treatment options for breast cancer patients. However, many lead to insufficient immune responses rendering the therapies incapable of completely eradicating tumors.

UCI researchers to join national effort to build atlas of human breast cells

University of California, Irvine researchers will help lead an unprecedented national effort to document the intricate cell types and states in breast tissue that underlie cancer. Compilation of the Human Breast Cell Atlas will be supported by a $4 million Seed Network grant from the Chan Zuckerberg Initiative.

Researchers discover new way to discriminate between mutations responsible for promoting cancer growth and those that are not

Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression. A new University of California, Irvine-led study indicates this is not always true.

UCI research helps shed new light on circadian clocks

Body parts respond to day and night independently from brain, studies show

UCI to establish skin biology, diseases resource center with $4 million NIH award

With nearly $4 million in funding from the National Institute of Arthritis & Musculoskeletal & Skin Diseases, the University of California, Irvine will establish the UCI Skin Biology Resource-based Center.

UCI-led study reveals how fasting can improve overall health and protect against aging-associated diseases

In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports.