Dec 21, 2022 | UC Irvine News

UC Irvine-led study links metabolism changes in certain brain cells to Huntington’s disease — Findings show high-dose thiamine and biotin treatments can restore normal processes

A research team led by the University of California, Irvine has linked the mutation that causes Huntington’s disease to developmental deficits in the brain’s oligodendrocyte cells that are caused by changes in metabolism.

Jul 13, 2022 | UC Irvine News

Research reveals how brain inflammation may link Alzheimer’s risk, sleep disturbance

Multisite team included UCI, University of Wisconsin–Madison, Wake Forest University

May 05, 2022 | UC Irvine School of Medicine

UCI researchers reveal possible molecular blood signature for suicide in major depression

New approach integrates blood and brain data to identify potential blood biomarkers.

Apr 12, 2022 | UC Irvine School of Medicine

UCI participates in landmark study that reveals clearest genetic signals yet for schizophrenia risk

This and another large genetic study point to similar genes and biological mechanisms that start to home in on the root causes of the severe psychiatric disorder.

Feb 09, 2022 | UC Irvine News

UCI study reveals neurobiological processes occurring during puberty that trigger sex differences in learning and memory

New findings suggest optimal teaching tactics, psychiatric treatment, should adapt to reflect brain differences.

Oct 22, 2020 | UC Irvine School of Medicine

NIH Awards Over $100 Million to Examine Biomarkers of Alzheimer’s Disease in Adults with Down Syndrome

The Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a multi-institution research team, co-led by members from the University of California, Irvine, has been awarded an unprecedented five-year, $109 million grant by the National Institutes of Health (NIH), to expand research on the biomarkers of Alzheimer’s disease in adults with Down syndrome.

Apr 11, 2019 | UC Irvine School of Medicine

UCI-led research team catalogs mitochondria deletions in the human brain using a single test

In a recent University of California, Irvine-led study published in Nucleic Acids Research, a team of scientists described a catalog of 4489 putative mitochondrial DNA (mtDNA) deletions, including their frequency and relative read rate. This catalog comprises the first comprehensive database of mitochondrial deletions derived from human brain.

Apr 09, 2019 | UC Irvine School of Medicine

Researchers discover neural patterns key to understanding disorders such as PTSD

Researchers at the University of California, Irvine have identified for the first time an imbalance in a key neural pathway that explains how some people reactivate negative emotional memories. The finding could help scientists unlock new ways to treat psychiatric disorders such as post-traumatic stress disorder.