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Rhodopsin, the light sensor of the mammalian visual system

Apr 06, 2022 | UC Irvine School of Medicine

UCI-led study could usher in new paradigm for drug discovery

Impact of native lipids on rhodopsin signaling and regeneration opens door to GPCR drug discovery in native membrane environments.
In vivo correction of an Rpe65 mutation

Apr 05, 2022 | UC Irvine School of Medicine

New UCI-led study lays foundation for establishing base editing as a one-time, durable treatment for inherited retinal degeneration

A new UCI-led study indicates base editing may provide long-lasting retinal protection and prevent vision deterioration in patients with inherited retinal degeneration, specifically in Leber congenital amaurosis (LCA) patients.

Tallie Z. Baram, distinguished professor in the Departments of Anatomy & Neurobiology, Pediatrics, Neurology, and Physiology & Biophysics at the UCI School of Medicine

Mar 29, 2022 | UC Irvine School of Medicine

UCI-led study links early life adversity, microglia dysfunction, to aberrant adult stress responses, mental illness

Targeting neuroimmune interaction during brain circuit maturation may provide treatment
KO ADP model Induced pluripotent stem cell-derived microglia

Mar 23, 2022 | UC Irvine School of Medicine

UCI-led study reveals how TREM2 gene mutation in brain microglia immune cells can increase Alzheimer’s risk

Findings show blocking excess calcium accumulation may be effective therapy.

Mar 15, 2022 | UCI Health

UCI Health gastroenterologist honored by the American Society of Gastrointestinal Endoscopy

The American Society of Gastrointestinal Endoscopy (ASGE) has named Dr. Kenneth Chang, board-certified UCI Health gastroenterologist and executive director of the UCI Health Digestive Health Institute, a Crystal Awards Master Endoscopist honoree.
A sample login page for the HOPE intervention program

Feb 25, 2022 | UC Irvine School of Medicine

New UCI study finds Harnessing Online Peer Education to be an effective tool for HIV prevention

Controlled trial shows increased HIV testing and reduced alcohol use among African American and Latinx MSM
Graphs showing performance in an Object Location Memory task

Feb 09, 2022 | UC Irvine News

UCI study reveals neurobiological processes occurring during puberty that trigger sex differences in learning and memory

New findings suggest optimal teaching tactics, psychiatric treatment, should adapt to reflect brain differences.
Dominik Lewandowski, PhD, postdoctoral scholar at the UCI School of Medicine.

Jan 26, 2022 | UC Irvine School of Medicine

UCI researchers discover cause, develop pharmacological treatment for reducing retinitis pigmentosa vision loss

Inhibiting ceramide accumulation in retina protects photoreceptors, improves vision
Farahnaz Rahmatpanah, PhD

Jan 11, 2022 | UC Irvine School of Medicine

UCI-led research team discovers a molecular feature in prostate cancer with prognostic value, distinguishes ancestral differences

Expression signatures may be useful for assessing greatest risk of progression in prostate and other cancers

Schematic summary of new hippocampal circuit connections that are revealed in the new PLOS Biology study

Jan 10, 2022 | UC Irvine School of Medicine

UCI-led team first to discover new neural circuits that regulate spatial learning and memory in the brain’s hippocampal formation

Understanding of novel functional roles can advance research in Alzheimer’s disease, other learning and memory disorders