Home Department
Psychiatry
Joint Appointments
- Biological Chemistry
- Neurobiology & Behavior
Leslie Thompson, PhD
- Professor, Psychiatry & Human Behavior
- Professor, Biological Chemistry
- Biotin
- Disease Models, Animal
- DNA Repair Enzymes
- Huntingtin Protein
- Huntington Disease
- Nerve Tissue Proteins
- Nervous System Diseases
- Nuclear Proteins
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Inhibitors of Activated STAT
- Receptor, Fibroblast Growth Factor, Type 3
- Small Ubiquitin-Related Modifier Proteins
- Spinocerebellar Ataxias
- Thiamine
- Wnt Signaling Pathway
- Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain. Nat Genet. 2025 Jan 14. Cui Y, Arnold FJ, Li JS, Wu J, Wang D, Philippe J, Colwin MR, Michels S, Chen C, Sallam T, Thompson LM, La Spada AR, Li W. PMID: 39809899.
- Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification. Nat Neurosci. 2025 Jan 06. Nguyen TB, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau AL, McClure NR, Wu Z, Wang KQ, England WE, Singha M, Stocksdale JT, Heath M, Jang KH, Jung S, Ling K, Jafar-Nejad P, McKnight JI, Ho LN, Dalahmah OA, Faull RLM, Steffan JS, Reidling JC, Jang C, Lee G, Cleveland DW, Lagier-Tourenne C, Spitale RC, Thompson LM. PMID: 39762660.
- Dysregulation of protein SUMOylation networks in Huntington's disease R6/2 mouse striatum. Brain. 2024 Oct 11. Kachemov M, Vaibhav V, Smith C, Sundararaman N, Heath M, Pendlebury DF, Matlock A, Lau A, Morozko E, Lim RG, Reidling J, Steffan JS, Van Eyk JE, Thompson LM. PMID: 39391934.
- Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease. bioRxiv. 2024 Sep 08. Shi Z, Das S, Morabito S, Miyoshi E, Stocksdale J, Emerson N, Srinivasan SS, Shahin A, Rahimzadeh N, Cao Z, Silva J, Castaneda AA, Head E, Thompson L, Swarup V. PMID: 39282421.
- Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2319091121. Fote GM, Eapen VV, Lim RG, Yu C, Salazar L, McClure NR, McKnight J, Nguyen TB, Heath MC, Lau AL, Villamil MA, Miramontes R, Kratter IH, Finkbeiner S, Reidling JC, Paulo JA, Kaiser P, Huang L, Housman DE, Thompson LM, Steffan JS. PMID: 39074279.
- Identifying dysregulated regions in amyotrophic lateral sclerosis through chromatin accessibility outliers. HGG Adv. 2024 Jul 18; 5(3):100318. Çelik MH, Gagneur J, Lim RG, Wu J, Thompson LM, Xie X. PMID: 38872308.
- HD and SCA1: Tales from two 30-year journeys since gene discovery. Neuron. 2023 11 15; 111(22):3517-3530. Thompson LM, Orr HT. PMID: 37863037.
- An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells. Hum Mol Genet. 2023 04 20; 32(9):1483-1496. Hernandez SJ, Lim RG, Onur T, Dane MA, Smith R, Wang K, Jean GE, Reyes-Ortiz A, Devlin K, Miramontes R, Wu J, Casale M, Kilburn D, Heiser LM, Korkola JE, Van Vactor D, Botas J, Thompson-Peer KL, Thompson LM. PMID: 36547263.
- Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2023 Mar 02; 14(1):1194. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 36864071.
- Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. Nat Commun. 2022 12 21; 13(1):7791. Lim RG, Al-Dalahmah O, Wu J, Gold MP, Reidling JC, Tang G, Adam M, Dansu DK, Park HJ, Casaccia P, Miramontes R, Reyes-Ortiz AM, Lau A, Hickman RA, Khan F, Paryani F, Tang A, Ofori K, Miyoshi E, Michael N, McClure N, Flowers XE, Vonsattel JP, Davidson S, Menon V, Swarup V, Fraenkel E, Goldman JE, Thompson LM. PMID: 36543778.
- Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. iScience. 2023 Jan 20; 26(1):105732. Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, Swarup V, Poon WW, Lim RG, Thompson LM. PMID: 36590162.
- Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins. J Cell Sci. 2022 01 15; 135(2). Fote GM, Geller NR, Efstathiou NE, Hendricks N, Vavvas DG, Reidling JC, Thompson LM, Steffan JS. PMID: 34982109.
- Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes. J Huntingtons Dis. 2022; 11(1):25-33. Wakida NM, Lau AL, Nguyen J, Cruz GMS, Fote GM, Steffan JS, Thompson LM, Berns MW. PMID: 35253772.
- Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice. J Virol. 2022 02 23; 96(4):e0196921. Olivarria GM, Cheng Y, Furman S, Pachow C, Hohsfield LA, Smith-Geater C, Miramontes R, Wu J, Burns MS, Tsourmas KI, Stocksdale J, Manlapaz C, Yong WH, Teijaro J, Edwards R, Green KN, Thompson LM, Lane TE. PMID: 34935438.
- Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice. bioRxiv. 2021 Nov 17. Olivarria GM, Cheng Y, Furman S, Pachow C, Hohsfield LA, Smith-Geater C, Miramontes R, Wu J, Burns MS, Tsourmas KI, Stocksdale J, Manlapaz C, Yong WH, Teijaro J, Edwards R, Green KN, Thompson LM, Lane TE. PMID: 34816260.
- Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease. Matrix Biol Plus. 2021 Dec; 12:100089. Hernandez SJ, Fote G, Reyes-Ortiz AM, Steffan JS, Thompson LM. PMID: 34786551.
- PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Kulkarni JA, Zaifman J, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, Lau A, St-Cyr S, Orellana I, Kopan L, Wang KQ, Yeung S, Leavitt BR, Reidling JC, Yang XW, Steffan JS, Davidson BL, Sarkar PS, Thompson LM. PMID: 33468657.
- Development and external validation of a prognostic tool for COVID-19 critical disease. PLoS One. 2020; 15(12):e0242953. Chow DS, Glavis-Bloom J, Soun JE, Weinberg B, Loveless TB, Xie X, Mutasa S, Monuki E, Park JI, Bota D, Wu J, Thompson L, Boden-Albala B, Khan S, Amin AN, Chang PD. PMID: 33296357.
- Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020 10 23; 11(1):5370. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 33097708.
- Calcium Dynamics in Astrocytes During Cell Injury. Front Bioeng Biotechnol. 2020; 8:912. Wakida NM, Gomez-Godinez V, Li H, Nguyen J, Kim EK, Dynes JL, Othy S, Lau AL, Ding P, Shi L, Carmona C, Thompson LM, Cahalan MD, Berns MW. PMID: 32984268.
- Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation. Stem Cell Reports. 2020 03 10; 14(3):406-419. Smith-Geater C, Hernandez SJ, Lim RG, Adam M, Wu J, Stocksdale JT, Wassie BT, Gold MP, Wang KQ, Miramontes R, Kopan L, Orellana I, Joy S, Kemp PJ, Allen ND, Fraenkel E, Thompson LM. PMID: 32109367.
- Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease. Brain. 2020 01 01; 143(1):266-288. Crapser JD, Ochaba J, Soni N, Reidling JC, Thompson LM, Green KN. PMID: 31848580.
- A short note for Mike. J Neurosci Res. 2019 Dec; 97(12):1748. Thompson LM. PMID: 31612586.
- IKKß slows Huntington's disease progression in R6/1 mice. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10952-10961. Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS. PMID: 31088970.
- Fractionation for Resolution of Soluble and Insoluble Huntingtin Species. J Vis Exp. 2018 02 27; (132). Ochaba J, Morozko EL, O'Rourke JG, Thompson LM. PMID: 29553509.
- Cellular Models: HD Patient-Derived Pluripotent Stem Cells. Methods Mol Biol. 2018; 1780:41-73. Geater C, Hernandez S, Thompson L, Mattis VB. PMID: 29856014.
- Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice. J Huntingtons Dis. 2018; 7(4):321-335. Morozko EL, Ochaba J, Hernandez SJ, Lau A, Sanchez I, Orellana I, Kopan L, Crapser J, Duong JH, Overman J, Yeung S, Steffan JS, Reidling J, Thompson LM. PMID: 30452420.
- Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. 2018 01 09; 10(1):58-72. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. PMID: 29233555.
- Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Rep. 2017 05 16; 19(7):1365-1377. Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. PMID: 28514657.
- PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo. Neuron. 2016 05 04; 90(3):507-20. Ochaba J, Monteys AM, O'Rourke JG, Reidling JC, Steffan JS, Davidson BL, Thompson LM. PMID: 27146268.
- Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes. Neuron. 2015 Jan 21; 85(2):303-15. Lee JH, Tecedor L, Chen YH, Monteys AM, Sowada MJ, Thompson LM, Davidson BL. PMID: 25556834.
- Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease. Hum Mol Genet. 2015 Mar 15; 24(6):1602-16. Liu KY, Shyu YC, Barbaro BA, Lin YT, Chern Y, Thompson LM, James Shen CK, Marsh JL. PMID: 25398943.
- Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16889-94. Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS. PMID: 25385587.
- Fibroblast growth factor receptor 3 interacts with and activates TGFß-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. PLoS One. 2014; 9(1):e86470. Salazar L, Kashiwada T, Krejci P, Meyer AN, Casale M, Hallowell M, Wilcox WR, Donoghue DJ, Thompson LM. PMID: 24466111.
- Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3027-36. Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM. PMID: 23872847.
- SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Rep. 2013 Jul 25; 4(2):362-75. O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu YZ, Dasso M, Bates GP, Difiglia M, Davidson B, Wanker EE, Marsh JL, Lima CD, Steffan JS, Thompson LM. PMID: 23871671.
- Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3077-82. Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM. PMID: 23365139.
- Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci. 2012 Aug 08; 32(32):11109-19. Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. PMID: 22875942.
- Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis. 2012; 1(2):221-41. Strong MK, Southwell AL, Yonan JM, Hayden MR, Macgregor GR, Thompson LM, Steward O. PMID: 23833693.
- Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. J Huntingtons Dis. 2012; 1(1):119-32. Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. PMID: 24086178.
- Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Neurodegener Dis. 2012; 9(2):104-6. Bodai L, Pallos J, Thompson LM, Marsh JL. PMID: 21912091.
- Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J Neurosci. 2011 May 04; 31(18):6858-70. Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR. PMID: 21543616.
- Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron. 2009 Dec 24; 64(6):828-40. Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. PMID: 20064390.
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28; 187(7):1083-99. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. PMID: 20026656.
- Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem. 2009 Oct 23; 284(43):29427-36. Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. PMID: 19710014.
- A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells. Hum Mol Genet. 2009 Jun 01; 18(11):1951-61. Salazar L, Kashiwada T, Krejci P, Muchowski P, Donoghue D, Wilcox WR, Thompson LM. PMID: 19286672.
- Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. PLoS One. 2008; 3(12):e3961. Krejci P, Salazar L, Kashiwada TA, Chlebova K, Salasova A, Thompson LM, Bryja V, Kozubik A, Wilcox WR. PMID: 19088846.
- Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 05; 28(45):11500-10. Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. PMID: 18987186.
- Animal models of polyglutamine diseases and therapeutic approaches. J Biol Chem. 2009 Mar 20; 284(12):7431-5. Marsh JL, Lukacsovich T, Thompson LM. PMID: 18957429.
- Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal. 2009 Jan; 21(1):151-60. Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, Thompson LM, Wilcox WR. PMID: 18950705.
- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet. 2008 Dec 01; 17(23):3767-75. Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL. PMID: 18762557.
- Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347. Mol Cell Neurosci. 2008 Sep; 39(1):1-7. Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, Cattaneo E. PMID: 18571429.
- CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice. Mol Cell Neurosci. 2008 Sep; 39(1):8-20. Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM. PMID: 18602275.
- Neurodegeneration: a question of balance. Nature. 2008 Apr 10; 452(7188):707-8. Thompson LM. PMID: 18401401.
- STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes. J Cell Sci. 2008 Feb 01; 121(Pt 3):272-81. Krejci P, Salazar L, Goodridge HS, Kashiwada TA, Schibler MJ, Jelinkova P, Thompson LM, Wilcox WR. PMID: 18198189.
- Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiol Dis. 2008 Mar; 29(3):391-9. McLin JP, Thompson LM, Lusis AJ, Davis RC, Steward O. PMID: 17996456.
- Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. J Biol Chem. 2007 Feb 02; 282(5):2929-36. Krejci P, Masri B, Salazar L, Farrington-Rock C, Prats H, Thompson LM, Wilcox WR. PMID: 17145761.
- Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains. Eur J Neurosci. 2006 Dec; 24(11):3134-40. McLin JP, Thompson LM, Steward O. PMID: 17156374.
- The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis. Hum Mol Genet. 2007 Jan 01; 16(1):61-77. Rockabrand E, Slepko N, Pantalone A, Nukala VN, Kazantsev A, Marsh JL, Sullivan PG, Steffan JS, Sensi SL, Thompson LM. PMID: 17135277.
- Transcription meets metabolism in neurodegeneration. Nat Med. 2006 Nov; 12(11):1239-41. Ross CA, Thompson LM. PMID: 17088887.
- Drosophila in the study of neurodegenerative disease. Neuron. 2006 Oct 05; 52(1):169-78. Marsh JL, Thompson LM. PMID: 17015234.
- Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14367-72. Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, Wetzel R. PMID: 16980414.
- Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum Mol Genet. 2006 Jul 01; 15(13):2114-24. Desai UA, Pallos J, Ma AA, Stockwell BR, Thompson LM, Marsh JL, Diamond MI. PMID: 16720620.
- Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum Mol Genet. 2006 Jan 15; 15(2):273-85. Apostol BL, Illes K, Pallos J, Bodai L, Wu J, Strand A, Schweitzer ES, Olson JM, Kazantsev A, Marsh JL, Thompson LM. PMID: 16330479.
- Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells. Hum Mol Genet. 2005 Jun 01; 14(11):1529-38. Nowroozi N, Raffioni S, Wang T, Apostol BL, Bradshaw RA, Thompson LM. PMID: 15843401.
- Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3777-81. Agrawal N, Pallos J, Slepko N, Apostol BL, Bodai L, Chang LW, Chiang AS, Thompson LM, Marsh JL. PMID: 15716359.
- A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):892-7. Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. PMID: 15642944.
- Can flies help humans treat neurodegenerative diseases? Bioessays. 2004 May; 26(5):485-96. Marsh JL, Thompson LM. PMID: 15112229.
- SUMO modification of Huntingtin and Huntington's disease pathology. Science. 2004 Apr 02; 304(5667):100-4. Steffan JS, Agrawal N, Pallos J, Rockabrand E, Trotman LC, Slepko N, Illes K, Lukacsovich T, Zhu YZ, Cattaneo E, Pandolfi PP, Thompson LM, Marsh JL. PMID: 15064418.
- A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron. 2003 Nov 13; 40(4):685-94. Pollitt SK, Pallos J, Shao J, Desai UA, Ma AA, Thompson LM, Marsh JL, Diamond MI. PMID: 14622574.
- Autophagy regulates the processing of amino terminal huntingtin fragments. Hum Mol Genet. 2003 Dec 15; 12(24):3231-44. Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M. PMID: 14570716.
- An expanded role for wild-type huntingtin in neuronal transcription. Nat Genet. 2003 Sep; 35(1):13-4. Thompson LM. PMID: 12947403.
- Invertebrate models of neurologic disease: insights into pathogenesis and therapy. Curr Neurol Neurosci Rep. 2003 Sep; 3(5):442-8. Thompson LM, Marsh JL. PMID: 12914688.
- Fly models of Huntington's disease. Hum Mol Genet. 2003 Oct 15; 12 Spec No 2:R187-93. Marsh JL, Pallos J, Thompson LM. PMID: 12925571.
- A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5950-5. Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. PMID: 12730384.
- Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases. Expert Opin Ther Targets. 2003 Apr; 7(2):201-13. Steffan JS, Thompson LM. PMID: 12667098.